SHORT PAPER
Year : 2003  |  Volume : 2  |  Issue : 1  |  Page : 7

Polymorphisms of the BRAF gene predispose males to malignant melanoma


1 Department of Dermatology, University Hospital of Tuebingen, Tuebingen; Institute of Human Genetics, University Hospital of Tuebingen, Tuebingen; Genefinder Technologies Ltd., Munich, Germany
2 Directorate of Laboratory Medicine, Bristol Royal Infirmary, Bristol, United Kingdom
3 Department of Dermatology, University Hospital of Tuebingen, Tuebingen, Germany

Correspondence Address:
Peter Meyer
Department of Dermatology, University Hospital of Tuebingen, Tuebingen; Institute of Human Genetics, University Hospital of Tuebingen, Tuebingen; Genefinder Technologies Ltd., Munich
Germany
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1186/1477-3163-2-7

The incidence of malignant melanoma has rapidly increased in recent years. Evidence points to the role of inheritance in melanoma development, but specific genetic risk factors are not well understood. Recent reports indicate a high prevalence of somatic mutations of the BRAF gene in melanomas and melanocytic nevi. Here we report that germ-line single nucleotide polymorphisms (SNPs) in BRAF are significantly associated with melanoma in German males, but not females. At-risk haplotypes of BRAF are shown. Based upon their frequencies, we estimate that BRAF could account for a proportion attributable risk of developing melanoma of 4% in the German population. The causal variant has yet to be determined. The burden of disease associated with this variant is greater than that associated with the major melanoma susceptibility locus C DKN2A , which has an estimated attributable risk of less than 1%.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5142    
    Printed331    
    Emailed0    
    PDF Downloaded597    
    Comments [Add]    
    Cited by others 43    

Recommend this journal