Year : 2008  |  Volume : 7  |  Issue : 1  |  Page : 1

BRAF V600E mutations in malignant melanoma are associated with increased expressions of BAALC

Department of Dermatology, Julius-Maximilians University, Würzburg, Germany

Correspondence Address:
David Schrama
Department of Dermatology, Julius-Maximilians University, Würzburg
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Source of Support: None, Conflict of Interest: None

DOI: 10.1186/1477-3163-7-1

Bachground: Activating BRAF mutations are present in approximately 50% of melanomas. Although different downstream target genes of the most common mutant V600E have been identified, the contribution of activating BRAF mutations to malignant transformation needs further clarification. Methods: Microarray gene analysis was performed for human melanoma cell lines harboring BRAF V600E mutations in comparison to cell lines without this mutation. Results: This analysis revealed a more than two fold down-regulation of 43 and an increase of 39 gene products. BAALC ( Brain and acute Leukaemia, cytoplasmatic ) was most prominently regulated, since it was up-regulated in mutated cell lines by a mean of 11.45. Real time PCR analyses with RNA from melanoma cell lines (n = 30) confirmed the BRAF -activation dependent up-regulation of BAALC . Conclusion: BAALC , which has been associated with cell dedifferentiation and migration, may function as a downstream effector of activating BRAF mutations during melanomagenesis.

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