REVIEW ARTICLE
Year : 2010  |  Volume : 9  |  Issue : 1  |  Page : 8

MicroRNAs and lung cancer: Biology and applications in diagnosis and prognosis


1 Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA
2 Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA
3 Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY; Department of Surgery, State University of New York at Buffalo, Buffalo, NY, USA

Correspondence Address:
Sai Yendamuri
Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY; Department of Surgery, State University of New York at Buffalo, Buffalo, NY
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1477-3163.67074

MicroRNAs are tiny non-coding RNA molecules which play important roles in the epigenetic control of cellular processes by preventing the translation of proteins from messenger RNAs (mRNAs). A single microRNA can target different mRNAs, and an mRNA can be targeted by multiple microRNAs. Such complex interplays underlie many molecular pathways in cells, and specific roles for many microRNAs in physiological as well as pathological phenomena have been identified. Changes in expression of microRNAs have been associated with a wide variety of disease conditions, and microRNA-based biomarkers are being developed for the identification and monitoring of such states. This review provides a general overview of the current state of knowledge about the biology of microRNAs, and specific information about microRNAs with regard to the diagnosis and prognosis of lung cancer.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed11324    
    Printed497    
    Emailed4    
    PDF Downloaded1641    
    Comments [Add]    
    Cited by others 15    

Recommend this journal