Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers

Hussain Almubarak¹, Antonia Jones¹, Risa Chaisuparat², Ming Zhang¹, Timothy F Meiller¹, Mark A Scheper^1
1 University of Maryland and the Marlene and Stewart Greenebaum Cancer Center, 650 W. Baltimore St., Baltimore, MD 21201, USA
² Chulalongkorn University, 254 Phyathai Rd., Patumwan, Bangkok, 10330, Thailand

Correspondence Address:
Mark A Scheper
University of Maryland and the Marlene and Stewart Greenebaum Cancer Center, 650 W. Baltimore St., Baltimore, MD 21201
USA

Source of Support: None, Conflict of Interest: None

Check

20

This is being retracted at the request of the author's university, which has determined that the article contains falsified figures and have requested for the article to retracted.

This article has been cited by 1 Lantana camara Induces Apoptosis by Bcl-2 Family and Caspases Activation Eun Byeol Han,Bo Yoon Chang,Young Suk Jung,Sung Yeon Kim Pathology & Oncology Research. 2014; [Pubmed] | [DOI] 2 Zoledronic acid induces apoptosis and autophagy in cervical cancer cells I-Te Wang,Shou-Chu Chou,Ying-Chin Lin Tumor Biology. 2014; [Pubmed] | [DOI] 3 Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate Takeshi Yokoyama,Andreas Ostermann,Mineyuki Mizuguchi,Nobuo Niimura,Tobias E. Schrader,Ichiro Tanaka Acta Crystallographica Section F Structural Biology Communications. 2014; 70(4): 470 [Pubmed] | [DOI] 4 The Anti-Tumour Effects of Zoledronic Acid Jamal Zekri,Maged Mansour,Syed Mustafa Karim Journal of Bone Oncology. 2014; [Pubmed] | [DOI] 5 Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB Schech, A.J. and Kazi, A.A. and Gilani, R.A. and Brodie, A.H. Molecular Cancer Therapeutics. 2013; 12(7): 1356-1366 [Pubmed] 6 Hyaluronan synthesis inhibitor supplements the inhibitory effects of zoledronic acid on bone metastasis of lung cancer Futamura, N. and Urakawa, H. and Arai, E. and Kozawa, E. and Ishiguro, N. and Nishida, Y. Clinical and Experimental Metastasis. 2013; 30(5): 595-606 [Pubmed] 7 Codelivery of zoledronic acid and double-stranded RNA from core-shell nanoparticles Chen, L. and Ding, Y. and Wang, Y. and Liu, X. and Babu, R.J. and Ravis, W.R. and Yan, W. International Journal of Nanomedicine. 2013; 8: 137-145 [Pubmed] 8 Hyaluronan synthesis inhibitor supplements the inhibitory effects of zoledronic acid on bone metastasis of lung cancer Naohisa Futamura,Hiroshi Urakawa,Eisuke Arai,Eiji Kozawa,Naoki Ishiguro,Yoshihiro Nishida Clinical & Experimental Metastasis. 2013; 30(5): 595 [Pubmed] | [DOI] 9 Zoledronic acid influences growth, migration and invasive activity of prostate cancer cells in vitro J Mani,S Vallo,K Barth,J Makarevic,E Juengel,G Bartsch,C Wiesner,A Haferkamp,R A Blaheta Prostate Cancer and Prostatic Diseases. 2012; 15(3): 250 [Pubmed] | [DOI] 10 Zoledronic acid inhibits aromatase activity and phosphorylation: Potential mechanism for additive zoledronic acid and letrozole drug interaction Amanda J. Schech,Brandon E. Nemieboka,Angela H. Brodie The Journal of Steroid Biochemistry and Molecular Biology. 2012; 132(3-5): 195 [Pubmed] | [DOI] 11 Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay Tanja Fehm,Manfred Zwirner,Diethelm Wallwiener,Harald Seeger,Hans Neubauer BMC Cancer. 2012; 12(1): 308 [Pubmed] | [DOI] 12 Involvement of the mevalonate pathway in the antiproliferative effect of zoledronate on ACHN renal cell carcinoma cells Fujita, M., Tohi, M., Sawada, K., Yamamoto, Y., Nakamura, T., Yagami, T., Yamamori, M., Okamura, N. Oncology Reports. 2012; 27(5): 1371-1375 [Pubmed] 13 Bisphosphonates: Prevention of bone metastases in breast cancer Gnant, M., Dubsky, P., Hadji, P. Recent Results in Cancer Research. 2012; 192: 65-91 [Pubmed] 14 Zoledronic acid inhibits aromatase activity and phosphorylation: Potential mechanism for additive zoledronic acid and letrozole drug interaction Schech, A.J. and Nemieboka, B.E. and Brodie, A.H. Journal of Steroid Biochemistry and Molecular Biology. 2012; 132(3-5): 195-202 [Pubmed] 15 Stathmin is involved in the cooperative effect of Zoledronic acid and gefitinib on bone homing breast cancer cells in vitro Oda, M. and Iwaya, K. and Kuchi, R. and Kobayashi, T. and Yoneda, T. and Nishikawa, K. and Matsubara, O. and Kohno, N. Journal of Bone Oncology. 2012; 1(2): 40-46 [Pubmed] 16 Zoledronic acid influences growth, migration and invasive activity of prostate cancer cells in vitro Mani, J. and Vallo, S. and Barth, K. and Makarević, J. and Juengel, E. and Bartsch, G. and Wiesner, C. and Haferkamp, A. and Blaheta, R.A. Prostate Cancer and Prostatic Diseases. 2012; 15(3): 250-255 [Pubmed] 17 Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay Fehm, T. and Zwirner, M. and Wallwiener, D. and Seeger, H. and Neubauer, H. BMC Cancer. 2012; 12(308) [Pubmed] 18 Activation of BKca channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells Ma, Y.-G. and Liu, W.-C. and Dong, S. and Du, C. and Wang, X.-J. and Li, J.-S. and Xie, X.-P. and Wu, L. and Ma, D.-C. and Yu, Z.-B. and Xie, M.-J. PLoS ONE. 2012; 7(5) [Pubmed] 19 Study of sequence-dependent in vitro effects of zoledronic acid and paclitaxel upon human nasopharyngeal carcinoma cell line HNE1 Huang, W.-L. and Li, X.-Y. and Wang, H.-B. and Lin, W. and Lin, W.-Z. and Lin, S.-L. and Lin, Y.-C. National Medical Journal of China. 2012; 92(16): 1133-1137 [Pubmed] 20 Molecular pathways associated with mortality in papillary thyroid cancer Nilubol, N., Sukchotrat, C., Zhang, L., He, M., Kebebew, E. Surgery. 2011; 150(6): 1023-1031 [Pubmed] 21 Hypercalcemia of malignancy: Patomechanism, symptoms and treatment # Szyszka-Barth, K., Spychalski, Ł., Hałas, J., Bryl, M., Ramlau, R. Onkologia Polska. 2011; 14(2): 103-106 [Pubmed] 22 Antitumor effects of bisphosphonates: From the laboratory to the clinic Berenson, J.R. Current Opinion in Supportive and Palliative Care. 2011; 5(3): 233-240 [Pubmed] 23 Antitumor effects of bisphosphonates James R. Berenson Current Opinion in Supportive and Palliative Care. 2011; 5(3): 233 [Pubmed] | [DOI] 24 Molecular pathways associated with mortality in papillary thyroid cancer Naris Nilubol,Chotiya Sukchotrat,Lisa Zhang,Mei He,Electron Kebebew Surgery. 2011; 150(6): 1023 [Pubmed] | [DOI] 25 Molecular markers that can be utilized in diet and dietary supplement research Moyad, M.A., Wojno, K.J. Urologic Clinics of North America. 2011; 38(3): 321-324 [Pubmed]