ORIGINAL ARTICLE
Year : 2018  |  Volume : 17  |  Issue : 1  |  Page : 6

A novel cancer syndrome caused by KCNQ1-deficiency in the golden Syrian hamster


1 Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
2 Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota; Comparative Pathology Shared Resource, Masonic Cancer Center, University of Minnesota, Duluth, MN, USA
3 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA

Correspondence Address:
Robert T Cormier
Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN
USA
Zhongde Wang
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, USTAR Building, 650 East 1600 North, Logan, UT
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcar.JCar_5_18

BACKGROUND: The golden Syrian hamster is an emerging model organism. To optimize its use, our group has made the first genetically engineered hamsters. One of the first genes that we investigated is KCNQ1 which encodes for the KCNQ1 potassium channel and also has been implicated as a tumor suppressor gene. MATERIALS AND METHODS: We generated KCNQ1 knockout (KO) hamsters by CRISPR/Cas9-mediated gene targeting and investigated the effects of KCNQ1-deficiency on tumorigenesis. RESULTS: By 70 days of age seven of the eight homozygous KCNQ1 KOs used in this study began showing signs of distress, and on necropsy six of the seven ill hamsters had visible cancers, including T-cell lymphomas, plasma cell tumors, hemangiosarcomas, and suspect myeloid leukemias. CONCLUSIONS: None of the hamsters in our colony that were wild-type or heterozygous for KCNQ1 mutations developed cancers indicating that the cancer phenotype is linked to KCNQ1-deficiency. This study is also the first evidence linking KCNQ1-deficiency to blood cancers.


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