Figure 6.

Correlation of cytoregR-induced expression of caspase-3 protease (CPP32) and apoptosis in adenocarcinoma cells. Cells were grown and treated with varying dilutions of cytoregR as described in the methods. Caspase-3 protease activation was determined by using a fluorescent substrate for caspase-like proteases as described in the methods. CPP32 expression correlated positively with percentage of apoptosis induction. Data points represent the means ± SEM of triplicates from two independent experiments.