ABSTRACT
Oral submucous fibrosis is a chronic, progressive, scarring disease that affects people of South-East Asia predominantly. It is a precancerous condition with significantly increased risk of cancer. Candida albicans is present as normal flora in the oral cavity in abundant amount. In cases of oral submucous fibrosis, the epithelium gets altered and due to this it is postulated that there is alteration in the Candidal adhesion to the affected mucosa. p53 expression in oral submucous fibrosis was evaluated and correlation if any was elicited among Candida subspecies and p53 expression. Thus in this study we have carried out a qualitative and quantitative analysis of candida and its subspecies along with p53 expression in OSMF. A total number of 20 diagnosed cases of oral submucous fibrosis were included. The samples for mycological examination were obtained using sterile cotton swab from lesion surface. Samples were inoculated in Sabourad dextrose agar medium. For the subspecies identification, growth or Chromagar were analyzed along with sugar assimilation. Biopsy were taken for the same patients and subjected to IHC staining for p53. The study is in progress. The expected results are: There is increase in p53 expression in OSMF as compared to normal mucosa. There is decrease in Candidal count in OSMF.Read More…