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  Indian J Med Microbiol
 

Figure 3: Gross and microscopic images of an intestinal T-cell lymphoma. Grossly (Panel A), extending from the intestinal wall through the serosa and mesentery, there are multifocal to coalescing white-beige masses (arrowheads), with focal areas of necrosis and hemorrhage (arrows). The tumors circumferentially surround the intestines (indicated by asterisks) which are occasionally moderately dilated and segmentally ulcerated (transmural). Histologically, the tumor consists of densely packed sheets of round to oval cells with scant basophilic cytoplasm (Panel A) that infiltrate the intestinal mucosa (Panel C, asterisk) and subjacent layers through to intestinal serosa. The cells show a uniform, intense immunolabeling of plasma membrane for CD3 (Panels C and D) (anti-CD3 antibody, DAKO/Agilent, Santa Clara, CA, USA; Cat# A0452). H and E, ×40 objective Panel B; CD3 immunolabeling with ×20 objective Panel C, and with ×40 objective Panel D

Figure 3: Gross and microscopic images of an intestinal T-cell lymphoma. Grossly (Panel A), extending from the intestinal wall through the serosa and mesentery, there are multifocal to coalescing white-beige masses (arrowheads), with focal areas of necrosis and hemorrhage (arrows). The tumors circumferentially surround the intestines (indicated by asterisks) which are occasionally moderately dilated and segmentally ulcerated (transmural). Histologically, the tumor consists of densely packed sheets of round to oval cells with scant basophilic cytoplasm (Panel A) that infiltrate the intestinal mucosa (Panel C, asterisk) and subjacent layers through to intestinal serosa. The cells show a uniform, intense immunolabeling of plasma membrane for CD3 (Panels C and D) (anti-CD3 antibody, DAKO/Agilent, Santa Clara, CA, USA; Cat# A0452). H and E, ×40 objective Panel B; CD3 immunolabeling with ×20 objective Panel C, and with ×40 objective Panel D