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  Indian J Med Microbiol
 

Figure 1: Role of estrogens and androgens and their respective receptors - estrogen receptor alpha and beta and androgen receptor, in glial tumorigenesis. estrogen receptor beta agonists shows protective effects, whereas, estrogen receptor alpha agonist appears pro-tumorigenic in glioma. Androgens and androgen receptor agonist enhance, whereas, androgen receptor antagonists seem to prove effective in controlling glial tumor burden. The bottom right shows the specificity protein 1 -CYP17A1-DHEA axis in promoting glioma progression. Overall, the activities of estrogen receptor beta, estrogen receptor alpha, and androgen receptor appear to influence the oncogenic route (progression/suppression) in glioma

Figure 1: Role of estrogens and androgens and their respective receptors - estrogen receptor alpha and beta and androgen receptor, in glial tumorigenesis. estrogen receptor beta agonists shows protective effects, whereas, estrogen receptor alpha agonist appears pro-tumorigenic in glioma. Androgens and androgen receptor agonist enhance, whereas, androgen receptor antagonists seem to prove effective in controlling glial tumor burden. The bottom right shows the specificity protein 1 -CYP17A1-DHEA axis in promoting glioma progression. Overall, the activities of estrogen receptor beta, estrogen receptor alpha, and androgen receptor appear to influence the oncogenic route (progression/suppression) in glioma