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  Indian J Med Microbiol
 

Figure 6: Schematic model of c-Cbl and Srcasm downregulation of Src-family tyrosine kinases (SFKs). c-Cbl promotes ubiquitination of SFKs and preferentially targets activated mutant forms for proteosomal degradation. Srcasm binds to activated SFKs and preferentially downregulates native kinases over activated mutant forms through lysosomal degradation. GAT: GGA and TOM1 domain; MVB: multi-vesicular body; P-phosphorylated tyrosine; RING: RING-finger motif; SH1: Src-homology 1 kinase domain; SH2: Src-homology 2 domain; SH3: Src-homology 3 domain; TKBD: tyrosine-kinase binding domain; U: ubiquitin; VHS: VPS-27, Hrs and STAM domain

Figure 6: Schematic model of c-Cbl and Srcasm downregulation of Src-family tyrosine kinases (SFKs). c-Cbl promotes ubiquitination of SFKs and preferentially targets activated mutant forms for proteosomal degradation. Srcasm binds to activated SFKs and preferentially downregulates native kinases over activated mutant forms through lysosomal degradation. GAT: GGA and TOM1 domain; MVB: multi-vesicular body; P-phosphorylated tyrosine; RING: RING-finger motif; SH1: Src-homology 1 kinase domain; SH2: Src-homology 2 domain; SH3: Src-homology 3 domain; TKBD: tyrosine-kinase binding domain; U: ubiquitin; VHS: VPS-27, Hrs and STAM domain