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  Indian J Med Microbiol
 

Figure 1: An illustration of SATB2 and Runt-related transcription factor 2 network in bone development. Runt-related transcription factor 2 and SATB2 share common upstream regulators such as MAPK/ERK pathway and bone morphogenetic protein/SMAD pathway, and they have overlapping downstream genes such as osteocalcin, bone sialoprotein, and COL1A1 in osteogenesis. They are connected by HOXA2, osterix, and various microRNAs in either direction, allowing Runt-related transcription factor 2 and SATB2 to act as an upstream regulator for one another. Among the microRNAs connecting SATB2 and Runt-related transcription factor 2, miR-31 and miR-23-27a ~24-2 have solid evidence supporting the pathway axis in osteoblast differentiation. In addition, SATB2 also displays physical interaction with Runt-related transcription factor 2 to regulate its transcription activity and induce the expression of osteocalcin

Figure 1: An illustration of SATB2 and Runt-related transcription factor 2 network in bone development. Runt-related transcription factor 2 and SATB2 share common upstream regulators such as MAPK/ERK pathway and bone morphogenetic protein/SMAD pathway, and they have overlapping downstream genes such as osteocalcin, bone sialoprotein, and COL1A1 in osteogenesis. They are connected by HOXA2, osterix, and various microRNAs in either direction, allowing Runt-related transcription factor 2 and SATB2 to act as an upstream regulator for one another. Among the microRNAs connecting SATB2 and Runt-related transcription factor 2, miR-31 and miR-23-27a ~24-2 have solid evidence supporting the pathway axis in osteoblast differentiation. In addition, SATB2 also displays physical interaction with Runt-related transcription factor 2 to regulate its transcription activity and induce the expression of osteocalcin